Sex-Based Differences in Bronchial Asthma: What Are the Mechanisms behind Them?

نویسندگان

چکیده

Sex-based differences in bronchial asthma can already be observed childhood, at which time allergic atopic is more frequently found boys than girls. In adulthood, higher prevalence of reported women, especially for the severe neutrophilic subtype associated with obesity, responds poorly to corticosteroids. seem attributable changing levels estrogens, progesterone, and testosterone, may exert mainly pro-inflammatory (estrogens, progesterone) or anti-inflammatory effects (testosterone). Sex steroids differentially influence lung immune responses, airway reactivity, pulmonary circulation thereby contribute susceptibility females serious complications resulting from inflammatory diseases compared males. However, other factors, such as anatomical physiological lungs, genetically conditioned obesity lifestyle, smoking, exposure environmental occupational chronic stress, etc., also sex-based asthma. Elucidation mechanisms behind these appropriate personalized therapy For review, articles English language PubMed database were used.

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ژورنال

عنوان ژورنال: Applied sciences

سال: 2023

ISSN: ['2076-3417']

DOI: https://doi.org/10.3390/app13042694